British research policy: Could do much better

Islam with the internet could do much to prevent disease.

Operations Research for stroke care systems: An opportunity for The Science of Better to do much better

Stroke is one of the three most common causes of death around the world and the sixth most common cause of disability worldwide. Building effective and efficient stroke care systems is a critical step in improving patient outcomes in the prevention, treatment, and rehabilitation of stroke. Despite what seems like a great potential forOperations Research (often referred to as The Science of Bett...

Cellular radiosensitivity: how much better do we understand it?

PURPOSE Ionising radiation exposure gives rise to a variety of lesions in DNA that result in genetic instability and potentially tumourigenesis or cell death. Radiation extends its effects on DNA by direct interaction or by radiolysis of H(2)O that generates free radicals or aqueous electrons capable of interacting with and causing indirect damage to DNA. While the various lesions arising in DN...

Spectral debugging: How much better can we do?

This paper investigates software fault localization methods which are based on program spectra – data on execution profiles from passed and failed tests. We examine a standard method of spectral fault localization: for each statement we determine the number of passed and failed tests in which the statement was/wasn’t executed and a function, or metric, of these four values is used to rank state...

Preventing invasive candida infections. Where could we do better?

Invasive candidiasis is associated with high mortality rates, ranging from 35% to 60%, in the range reported for septic shock. The epidemiology and pathogenesis of invasive candidiasis differ according to the patient's immune status; the majority of cases in immunocompromised hosts are candidaemia, whereas non-candidaemic systemic candidiasis accounts for the majority of cases in critically ill...